Quotes of the Day

Guess which prescribed medication is the most common sleep medication. It's an FDA-approved antidepressant with no FDA approval for sleep. It's trazadone. Another is Remeron. The great thing about Remeron is that its name implies that taking it will turn REM on. Unfortunately, it all too often turns on weight gain too. The new fun thing to do is to skip the antidepressants and go right to the antipsychotics. Drugs like Seroquel (quetiapine), Zyprexa, and Risperdal (risperidone), which used to be used exclusively for patients with mania or psychosis, are now being used off label to treat simple insomnia. [2017] - W. Chris Winter

Bond yields more likely stay extremely low for a long time to come, and possibly go even lower I believe that low interest rates are mainly the result of an aging population, not the Great Recession and not COVID-19. Having more people who are over age 50 changes the balance of supply and demand for money, since older people tend to be savers rather than borrowers. Our ratio of older to younger people now is very similar to what it was in Japan 20 years ago. Interest rates there 20 years ago were about the same as ours are today, and their rates have hovered near zero ever sine. [2020] - Frederick Vettese

Most hosts are going to lean toward a small property management company that manages between 5 and 70 properties. This type of company is probably a good fit for anyone who has less than 20 properties that need managed. [2023] - Symon He

Three studies found no weight loss or cardiometabolic benefits on a 16/8 eating pattern (16 hours of fasting, 8 hours to eat). One other study did find that shifting the eating window to early in the day, from 8 am to 2 pm, actually did result in lower 24-hour glucose levels, reduced glucose excursions, and lower insulin levels compared to controls. So perhaps an early-day feeding window could be effective, but in my view 16 hours without food simply isn't long enough to activate autophagy or inhibit chronic mTOR elevation. Another drawback is that you're virtually guaranteed to miss your protein target with this approach. [2023] - Peter Attia

Don't pat when you hug (it subliminally signals that you want to disconnect). [2009] - Leil Lowndes