Quotes of the Day

Connections between stock and business profits correlate strongly over long time periods—15 years or more. But short term (and 10 years is considered a stock market blip), markets are mad because people are crazy. [2018] - Andrew Hallam

Sending things in the mail is usually a complete waste of time and money, unless you are selling from a distance. When the prospect asks if you could mail something, respond by saying, "I would love to mail it to you, but you know how undependable the mail can be today. Why don't I drop it off to you personally on Tuesday afternoon when I'm in the area? Will you be available at that time?" [2004] - Brian Tracy

A regular, reliable source of vitamin B12 is critical for anyone eating a plant-based diet. For adults under age 65, the easiest way to get B12 is to take at least one 2,500 mcg supplement each week. If you'd rather get into the habit of taking it daily, the once-a-day dosing is 250 mcg. Note that these doses are specific to cyanocobalamin, the preferred supplement form of vitamin B12, as there is insufficient evidence to support the efficacy of the other forms, like methylcobalamin. For those over 65 who eat plant-based diets, the supplementation should probably be increased up to 1,000 mcg of cyanocobalamin each day. [2015] - Michael Greger

Erythritol is derived from corn, and because the body does not recognize this product, it will be touted as calorie-free. Like all zero-calorie products, this may not be a healthy attribute, and I do not promote erythritol or suggest you mix it with xylitol or allow yourself to be swayed by research that asks you to believe that erythritol is superior to xylitol. [2018] - Ellie Phillips

Multicancer Early Detection (MCED) assays are constantly getting refined. There are also assays that detect certain proteins or metabolic markers, such as glycosaminoglycans, that indicate a higher likelihood that cancer may be present, as well as blood tests that combine cell-free tumor DNA and proteins in a panel. The test with the most extensive clinical experience to date is known as the GRAIL Galleri. It uses AI to determine whether there is a "cancer signal" and, if present, to help localize its likely organ source. The problem with this test that is marketed for $949 for people aged 50 and older is that the yield is remarkably low. Only 5 per 1,000 people test positive, and, of these, just 2 per 1,000 were actually diagnosed early, in stage 1 or 2, before the cancer spread. The proportion of false negatives among every 1,000 people tested is unknowable. [2025] - Eric Topol